Caffeine Anhydrous Powder
Product Specifications
DFI-336232DFI-391269DFI-155232DFI-992418
DFI-336232
| Description | |
|---|---|
| Appearance: | White or almost white crystalline powder or silky white or almost white crystal. |
| Appearance of solution: | Solution 'S' is clear and colourless |
| Chemical name: | 1H-purine-2, 6-dione, 3, 7-dihydro-1, 3, 7-trimethyl- |
| Country of origin: | India |
| Formula: | C8H10N4O2 |
| Molecular weight: | 194.19 |
| Packaging: | Packed in a double polythene bag and kept in fibre drums |
| Shelf life: | 60 Months |
| Storage: | Preserve anhydrous Caffeine in well closed containers |
| Specifications | |
| Acidity: | Not more than 0.2 ml of 0.01 ml sodium hydroxide is required to change the colour of the indicator to blue |
| Assay: | Not less than 98.5% and not more than 101.0% calculate on anhydrous basis |
| Assay: | Not less 98.5 % and not more than 101.5% of C8H10N4O2 calculate with reference to dried substance |
| Chloroform: | Max: 60ppm, mg/kg |
| Chromatographic purity: | Max: 0.1% |
| Chromatographic purity: | Max: 0.1% |
| Heavy metals: | Max: 0.001% |
| Identification A: | The infrared absorption spectrum |
| Identification A: | By melting point: 235°C to 239°C |
| Identification B: | The retention time of the caffeine peak in the chromatogram of the assay preparation correspond to that in the chromatogram of the standard preparation as obtained in the assay |
| Identification B: | IR Infrared spectrum |
| Identification C: | By Chemically |
| Identification D: | By Chemically |
| Identification E: | Complies to the test for loss on drying |
| Identification F: | Reaction xanthines |
| Impurity A: | Max: 0.1% |
| Impurity C: | Max: 0.1% |
| Impurity D: | Max: 0.1% |
| Impurity F: | Max: 0.1% |
| Loss on drying: | Max: 0.5% |
| Other Impurities: | Max: 0.1% |
| Related Substances: | Liquid chromatography (unspecified impurity) |
| Residue on ignition: | Max: 0.1% |
| Solubility: | Sparingly soluble in water freely soluble in boiling water, slightly soluble in ethanol 96%. It dissolves in concentrated solution of alkali benzoate or salicylate |
| Solubility: | Sparingly soluble in water and alcohol, freely soluble in chloroform, slightly soluble in ether |
| Sulphate: | Max: 500ppm, mg/kg |
| Sulphated ash: | Max: 0.1% |
| Total Impurities: | Max: 0.1% |
| Water: | Max: 0.5% |
| Microbiological | |
| Bacterial Count: | Max: 1000cfu/gm |
| Candida albicans: | Should be Absent |
| Escherichia Coli: | Should be Absent |
| P.aeruginosa: | Should be Absent |
| Salmonella: | Should be Absent |
| Staphylococcus aureus: | Should be Absent |
| Total yeasts and moulds: | Max: 100cfu/gm |
Published Date: 2021-03-11 16:24:17
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DFI-391269
| Description | |
|---|---|
| Appearance of solution: | Solution S is clear and colourless |
| CAS No.: | 58-08-2 |
| Chemical name: | 1,3,7- Trimethylxanthine |
| Country of origin: | China |
| Description: | Caffeine is white to almost white, crystalline powder or silky white or almost white,crystals, weathering |
| Formula: | C8H10N4O2 |
| Molecular weight: | 194.19 |
| Odour: | Odourless |
| Packaging: | 20kg/carton, 25kg/drum |
| Shelf life: | 60 months |
| Storage: | Keep in tightly closed container, stored in a natural temperature, ventilated area |
| Specifications | |
| Acidity: | Not more than 0.2mL of 0.01 M sodium hydroxide is required to change the colour of the indicator to blue. |
| Alkaloids: | Compliance |
| Any impurity: | <= 0.5 times the area of solution (a) (10%) |
| Assay: | 99 to 101% |
| Carbonisation: | Compliance |
| Heavy metals: | Max: 10ppm,mg/kg |
| Identification A: | The sample spectrum complies with that of the reference standard spectrum |
| Identification B: | The retention time of the caffeine peak of the sample solution corresponds to that of the standard solution |
| Individual Impurity: | Max: 0.1% |
| Individual Impurity: | Max: 0.1% |
| Melting point: | 235 to 237.5°C |
| Solubility: | Soluble in basic Benzoate or Salicylate |
| Solubility in Ethanol: | Slightly soluble in Ethanol (96%) |
| Solubility in Water: | Soluble in boiling water |
| Solubility in Water: | Insoluble in water |
| Sulfate: | Max: 500ppm,mg/kg |
| Sulphated ash: | Max: 0.1% |
| Total impurities: | Max: 0.1% |
| Total impurities: | Max: 0.1% |
| Water: | Max: 0.5% |
| Microbiological | |
| Escherichia Coli: | Not detected |
| Total Aerobic Bacteria: | Max: 800cfu/g |
| Yeasts & Moulds: | Max: 80cfu/g |
Published Date: 2021-02-15 10:49:33
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DFI-155232
| Description | |
|---|---|
| Appearance: | White crystalline powder |
| Appearance of solution: | Clear and colourless |
| CAS No.: | 58-08-2 |
| Country of origin: | China |
| Formula: | C8H10N4O2 |
| Molecular weight: | 194.19 |
| Shelf life: | 48 months |
| Specifications | |
| Acidity: | Max: 0.2 |
| Assay: | 98.5 to 101% |
| Assay: | 98.5 to 101.5% |
| Chromatographic purity: | Max: 0.1% |
| Heavy metals: | Max: 0.001% |
| HPLC: | Conforms to the chromatogram of the standard preparation |
| Identification: | Conforms to reference spectrum |
| Loss on drying: | Max: 0.5% |
| Melting point: | 234 to 239°C |
| Residual solvents: | Max: 60ppm, mg/kg |
| Residue on ignition: | Max: 0.1% |
| Sulfate: | Max: 500ppm, mg/kg |
| Sulphated ash: | Max: 0.1% |
| Total Impurities: | Max: 0.1% |
Published Date: 2021-06-28 15:56:25
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DFI-992418
| Description | |
|---|---|
| Appearance: | White crystalline powder or silky, white crystals |
| Appearance of solution: | Clear, colourless |
| CAS No.: | 58-08-2 |
| Chemical name: | 1,3,7-Trimethyl-3,7-dihydro-1H-purine-2,6-dione |
| Country of origin: | China |
| Formula: | C8H10N4O2 |
| Molecular Mass: | 194.2 |
| Packaging: | 20kg or 25kg cardboard box/drum |
| Shelf life: | 48 months |
| Storage: | Keep in a tightly closed container, store in a natural temperature, ventilated area. Protect against physical damage. Containers of this material may be hazardous when empty, since they retain product residues (dust, solids); observe all warnings and precautions listed for this product |
| Specifications | |
| Acidity: | Not more than 0.2 ml of 0.01 M sodium hydroxide |
| Alkaloids: | No precipitate is formed |
| Assay: | 98.5 to 101% |
| Identification A: | Conforms to the USP caffiene RS |
| Identification B: | Corresponds to the standard preparation obtained in the assay |
| Impurities: | Max: 0.1% |
| Individual Impurity: | Max: 0.1% |
| Lead: | Max: 1mg/kg, ppm |
| Loss on drying: | Max: 0.5% |
| Melting point: | 235 to 237.5°C |
| Readily Carbonisable Substances: | Qualified |
| Solubility: | Sparingly soluble in water, freely soluble in boiling water, slightly soluble in ethanol (96%). It dissolves in concentrated solutions of alkali benzoates or salicylates. It sublimes readily |
| Sulfate: | Max: 500ppm, mg/kg |
| Sulphated ash: | Max: 0.1% |
| Total impurities: | Max: 0.1% |
| Total impurities: | Max: 0.1% |
| Unspecified Impurity: | Max: 0.1% |
Published Date: 2023-06-27 08:19:12
